Pharmaceutical Grade Chlorhexidine Gluconate powder CAS 18472-51-0
Chlorhexidine Gluconate is the gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical
antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell
surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and
causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they
are more sensitive to this agent.
Chlorhexidine gluconate is a germicidal mouthwash that reduces bacteria in the mouth. Chlorhexidine gluconate oral rinse is used
to treat gingivitis (swelling, redness, bleeding gums).
Chlorhexidine Gluconate is the gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical
antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell
surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and
causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they
are more sensitive to this agent.
Chlorhexidine gluconate is a germicidal mouthwash that reduces bacteria in the mouth. Chlorhexidine gluconate oral rinse is used
to treat gingivitis (swelling, redness, bleeding gums).
Chlorhexidine gluconate Specifications
Test Item | Standard Code | Test Result |
Character | Colorless to light yellow almost clarify and slightly sticky liquid,odourless or almost odourless. | Light yellow and almost clarify slightly sticky liquid,odourless. |
| The product is miscible with water,dissolved in ethanol or propanol. | Confirm |
Relative Density | 1.060~1.070 | 1.064 |
Identify | 1.2.3. should be positive reaction. | Confirm |
Acidity |
pH 5.5~7.0
| pH=6.27 |
P-chloroaniline | Should confirm the rule 25ppm max | 15ppm |
Related Substance | Total impurities less than 3% | 0.85% |
Residue on ignition | 0.1%max | 0.01% |
Assay Chlorhexidine Gluconate | 19.0%~21.0%(g/ml)
| 20.3(g/ml) |
Conclusion | Testing according to the China Pharmacopeia,Secunda Partes,2015. Result:Confirm | |